Abstract
Experimental kinetic isotherms of adsorption for the drug molsidomine on phenyl-modified and unmodified mesoporous silica materials at pH 4.8, 6.0, 7.4, and 8.0 are obtained. It is shown that a pseudo-second-order model offers the best fit to the kinetic isotherms (with a correlation coefficient of >0.99) for all of the studied materials and at virtually all pH. The effects of synthesis route of the phenyl-modified silica materials (grafting or co-condesation) and medium pH on the adsorption capacity of the adsorbents and the second-order rate constant are studied. It is found that film diffusion is the rate-limiting step of molsidomine adsorption on phenyl-modified silica materials at all pH, while the role of pore diffusion increases with increasing pH.
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