Abstract
Liver PK had hyperbolic saturation curves with both substrates and was not sensitive to alanine, but was inhibited by ATP (I 50 = 6 mM). Both white and red muscle PK showed hyperbolic saturation curves with PEP and ADP, and were not activated by FDP but were inhibited by ATP (I 50 values were 2.3 and 5.6 mM, respectively). Varying Mg 2+ concentrations in muscle and liver PK always showed sigmoidal kinetics, whereas with Mn 2+ only the liver PK saturation curve was sigmoidal. Ca 2+ was an inhibitor of both liver and muscle PK. Cu 2+ and Zn 2+ had an inhibitory effect on liver and muscle PK. The I 50 values were of the same order but slightly lower for liver.
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