Abstract
Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology. The disease is mainly endemic in Asia, cases have been reported in Europe and America. The present case is of a 75 year Indian male who presented with cervical and axillary lymphadenopathy. Ultrasonography was done which showed multiple peritoneal lymph nodes. Peripheral smear showed eosinophilia. Cytomorphology and histopathology showed features of Hodgkin’s disease. S IgE level was raised. 5 years earlier patient had presented with similar complaints of generalized lymphadenopathy, raised IgE level, peripheral eosinophilia. FNAC of cervical lymph node done earlier showed cytomorphology of Reactive Lymphadenitis. Biopsy showed histology of Kimura’s disease.
Highlights
Kimura’s disease is a benign chronic inflammatory disorder attributed to an immune- mediated hypersensitivity [1]
We report a case of 72 years male who had unusual presentation of generalised lymphadenopathy
Kimura disease was first described in 1937 by Kim and Szeto (China) as eosinophilic hyperplastic granuloma, its histological description was given by Kimura (Japan) in 1948[2,3]
Summary
Kimura’s disease is a benign chronic inflammatory disorder attributed to an immune- mediated hypersensitivity [1]. Peripheral blood eosinophilia and increased serum immunoglobulin E (IgE) levels are always seen in Kimura’s disease [7]. It has to be differentiated from other conditions mainly lymphoma. 2. Case report A 72 year old male patient presented with cervical and axillary lymph nodes enlargement, mild fever, itching. On retrospective study of the previous H&E section of biopsy and related clinical and other laboratory findings, diagnosis of Kimura’s disease was made. This is a very rare presentation of Kimura’s disease in an elderly patient presenting with generalized lymphadenopathy, peripheral eosinophilia and increase in S. The patient has completed chemotherapy for Hodgkin’s disease with complete remission of the lymph nodes
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