Abstract
While amphibians regenerate lost appendages spontaneously, mammals generally scar over the injury site via wound repair. Inspired by the spontaneous healing trait of amphibians, we are developing self-assembling polymer prodrugs for delivery of a HIF1a agonist. The polymers self-assemble into filament-like nanostructures as determined by small-angle x-ray scattering (SAXS), driven by the hydrophobic nature of the conjugated drug. Entanglement of nanofibrils result in a viscoelastic, shear-thinning material, suitable for liquifying during passage through a needle. Subcutaneous injection of drug-hydrogel resulted in enhanced regenerative wound healing in non-regenerative mice, in a manner that emulates the basic elements of amphibian regeneration. These approaches offer new opportunities for delivery of tissue regenerative therapeutic drugs.
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