Abstract
Cervical cancer is an urgent problem due to its high morbidity, its growth tendency in women of reproductive age, and late presentation. As a result of insufficiently effective surgical and/or radiation treatment of the primary tumor, local recurrences occur in 10-40% of treated patients, and distant metastases in 35% of patients [10]. The first place according to the frequency of distant metastasis in RCC patients is occupied by para-aortic lymph nodes (31.2%), the second - lungs (16.1%), the third - bones (12.9%) [9]. Treatment of recurrent and generalized cervical cancer is a complex and unresolved problem of modern oncology due to the extremely limited range of possible therapeutic measures. The leading role in conservative therapy of cervical cancer relapses and metastases is played by highly toxic, but not specific cytostatics, which aggravates the condition of patients and the immunological failure of the organism [11].
Highlights
A retrospective study in 67 patients diagnosed with cervical cancer was carried out in this article and the effect of lymphoid infiltration in biopsy specimens was studied
Tumor tissues are infiltrated with large numbers of immune cells, it is still difficult to prevent invasion and metastasis of tumor cells, suggesting that tumor cells may escape observation and destruction by immune cells
To identify the immune cells of interest, specific antigens expressed on the cell surface were detected using Immunohistochemical examination (IHC), assuming that tissue antigen identification is possible with appropriate antibodies
Summary
A retrospective study in 67 patients diagnosed with cervical cancer was carried out in this article and the effect of lymphoid infiltration in biopsy specimens was studied. There are several well-known prognostic factors ( clinical stage, lymph node status, tumor size and depth of invasion, bcl-2, p53, KI-67, VEGF), but they do not always indicate an increased risk of cervical cancer patients recurrence. Despite recent advances in the immune mechanisms of cervical cancer (CRC), recurrence is still a pressing issue, and recognition of new prognostic biomarkers is essential. Obtaining thorough and detailed information about tumor-associated lymphocytes, the state of which is responsible for the cellular immune system in patients with relapsed cervical cancer, is an urgent goal. Purpose of study: Study of cellular immune response using DM 20 and DM 3 markers for early prognosis of cervical cancer recurrence
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