Abstract
With rare exceptions, each lymphocyte is destined to express only one antigen-receptor specificity for life, but the mechanisms by which this is enforced have not been fully resolved. During B-cell development, immunoglobulin gene segments ? variable (V), diversity (D) and joining (J) ? recombine to form functional immunoglobulin genes, generating a diverse B-cell repertoire. Regulated expression of the recombination activating genes (RAG1 and RAG2) during B-cell development helps to ensure that each B cell expresses a single heavy (IgH) chain and a single light-chain (Ig or Ig) allele, a phenomenon known as allelic exclusion. Now, reporting in Nature Immunology, Skok et al. provide the first evidence that epigenetic mechanisms could reinforce monoallelic expression of immunoglobulin genes at later stages.
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