Abstract
In vitro fertilization (IVF) requires superovulation to create adequate gametes for transfer. Several groups have suggested that this process may cause epigenetic changes that could have negative health outcomes for offspring. However, studies have also demonstrated epigenetic modifications are important to the process of normal gametogenesis. The study objectives were to assess expression of the histone demethylases KDM4A and KDM4B in granulosa collected from women undergoing oocyte retrieval and to determine if expression correlated with pregnancy outcome.
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