Kaposi sarcoma among people living with HIV in the French DAT'AIDS cohort between 2010 and 2015.

Isabelle Poizot‐Martin ,I Lamaury,D Rey,C Lions,Olivier Baud ,S Sausse ,Cédric Arvieux ,A S Brunel ,F Louni ,Roland Tubiana ,F Ajana ,V Rio ,Patrice Muret ,A Foltzer ,Éric Rosenthal ,Agathe Becker ,Marie André ,C Rioux ,Christine Katlama ,E Sidani ,Sylvie Brégigeon ,Corinne Merle De Boever ,Sylvie Pillet ,Jade Ghosn ,T Bonijoly ,V Mondain ,Lorena Porte ,Samira Fafi‐Kremer ,Romain Guéry ,Isabelle Fabre ,Yann Quertainmont ,Amélie Duréault ,Christian Pradier ,A Soria ,Christian Rabaud ,Olivia Zaegel-Faucher ,C Michelangeli ,B Bonnet ,A Ivanova ,C Etienne ,J Lourenco ,Élisa Demonchy ,Sylvie Lariven ,Laurent Hustache‐Mathieu ,David Boutoille ,Philippe Colson ,Catherine Tamalet ,Natacha Mrozek ,Benoît Tressières ,C Boulard ,Laurence Bocket ,M Pradier ,Diane Descamps ,Anne Gervais ,V Corbin ,Hélène Laroche ,M Priester ,Bruno Hoën ,Jacques Reynes ,N Meftah ,M Poinot ,Perrine Parize ,Yazdan Yazdanpanah ,P Morineau ,Édouard Tuaillon ,Paul Loubet ,N Viget ,Yohan N’guyen ,Karine Sauné ,Sophie Matheron ,Nathalie Lerolle ,Rachida Ouissa ,M Poisson-Vanier ,C Ceppi ,I Alcaraz ,Florence Ader ,Anne Galinier ,L Lelièvre ,K Guitteaud ,Olivier Lesens ,Nadine Atoui ,Sylvie Le Gac ,Faouzi Souala ,Christian Chidiac ,C Brochier ,C Clavel ,Olivier Lortholary ,Marina Illiaquer ,M Partisani ,Sébastien Galie ,Paul‐Henri Consigny ,K Jidar ,Aymeric Sève ,Gladys Thomas ,Jean-Luc Berger ,C Louisin ,Éric Cua ,Thierry May ,A Madrid ,Anne Maillard ,E De Mautort ,Ornella Cabras ,Laurent Hocqueloux ,G Cessot ,F Lemaître ,Cécile Brunet-Cartier ,P Dellamonica ,Karine Risso ,Claire Triffault-Fillit ,Charlotte Pronier ,M Baldeyrou ,Brigitte Montès ,Catherine Chirouze ,S Léautez ,Lydia Osei ,Claudine Bernard-Henry ,L Boyer ,A S Ritleng ,B Prouvost-Keller ,Antoine Chéret ,Kévin Bouiller ,Jean-Marc Chapplain ,Aude Raoux ,S Casanova ,A Frésard ,François Raffi ,Stephen J Ferrando ,François Bénézit ,Philippe Bossi ,Luminita Schneider ,Florent Valour ,Marie-Laure Batard ,Amélie Ménard ,Sylvie Abel ,C Mackoumbou-Nkouka ,Sabelline Bouchez ,Nazan Tuna Oran ,Elina Teicher ,M Delestan ,P Choisy ,Caroline Charlier ,J Prouteau ,T Jovelin ,Benoît Pilmis ,R Garraffo ,Christine Jacomet ,Guillaume Martin‐Blondel ,Virginie Ferré ,O Aubry ,Ana Ferrer ,L Laine ,A De Monte ,N Biezunski ,Agnés Meybeck ,M C Receveur ,Clotilde Allavena ,Ernesto Paredes ,M Martin-Degioanni ,M J Ducassou ,Anne Motte ,M Orticoni ,Colin Deschanvres ,P Martinet ,Gilles Peytavin ,Sophie Seang ,V Baclet ,P Roger ,Marc‐Antoine Valantin ,Jérémie Pasquier ,Katherine De Rome ,Olivier Grossi ,F Biron ,O Deradji ,J Durant ,Zélie Julia ,Cyrille Delpierre ,Véronique Joly ,Marine Morrier ,Anne Boucher ,V Ronat ,C Blanc ,A Boibieux ,Pascal Puglièse ,P Lansalot ,C Bernaud ,S Bréaud ,Christelle Tomei ,C Drobacheff-Thiébaut ,C Guennoun ,M Piffaut ,Alissa Naqvi ,H Laurichesse ,François Danion ,Firouzé Bani‐Sadr ,Stanzi M Le Roux ,Audrey Rodallec ,M P Bouillon ,I Jaquet ,Pierre Delobel ,Cécile Herrmann-Storck ,I Kmiec ,S Degroodt ,Julia Goesch ,Philippe Vande Perre ,Elodie Curlier ,M Bistoquet ,B Lafon‐Desmurs ,Quentin Lepiller ,Karima Amazzough ,Bonnie Henry ,Rachid Agher ,Charlotte Charpentier ,F Boulard ,E Ressiot ,F Touam ,C Varache ,I Perbost ,Thomas Perpoint ,G Benabdelmoumen ,C Debreux ,Roland Landman ,André Cabie ,Pierre Tattevin ,María Amparo Gómez Vidal ,Alexa Debard ,G Zouzou ,Laurent Cotte ,E Aïssi ,Marta Álvarez ,J P Sinteff ,Élisabeth André-Garnier ,Éric Delaporte ,M Lefèbvre ,F.-X Lescure ,Thiérry Prazuck ,Éric Billaud ,C Daniel ,Cécile Goujard ,Patrick Miailhes ,Maxime Hentzien ,C Gubavu ,S Wehrlen-Pugliese ,Patricia Fischer ,D Lambert ,J M Turmel ,A Y Belkhir ,Thomas Guimard ,H Tissot Dupont ,Mark B Landon ,Romain Palich ,Tristan Ferry ,Naomi M Hall ,Magali Dupont ,Charlotte Biron ,Alain Makinson ,O Babre ,Aurélie Barrail-Tran ,Line Meddeb ,Catherine Dhiver ,S Sécher ,P Letertre‐Gibert ,Lise Cuzin ,M Mokhtari ,Véronique Reliquet ,M Revest ,Fanny Lanternier ,Christine Cheneau ,A Maka ,C Auméran ,Vanessa Obry ,Isabelle Touitou ,M.j Soavi ,O Bollangier ,Thomas Huleux ,Vincent Le Moing ,David Chirio ,F Bozon ,Isabelle Ravaux ,Claudine Duvivier ,Dominique Merrien ,P Geneau De Lamarlière ,Olivier Robineau ,M Cavellec ,Solène Patrat-Delon ,F Lucht ,Sandrine Pierre-François ,A Brunet ,Véronique Brodard ,Amandine Gagneux‐Brunon ,Élisabeth Botelho-Nevers ,M Valette

doi:10.1111/jdv.16204

Abstract

BackgroundAlthough antiretroviral therapy (ART) has reduced the risk of Kaposi sarcoma (KS), KS cases still occur in HIV‐infected people.ObjectiveTo describe all KS cases observed between 2010 and 2015 in a country with high ART coverage.MethodsRetrospective study using longitudinal data from 44 642 patients in the French Dat’AIDS multicenter cohort. Patients’ characteristics were described at KS diagnosis according to ART exposure and to HIV‐plasma viral load (HIV‐pVL) (≤50 or >50) copies/mL.ResultsAmong the 209 KS cases diagnosed during the study period, 33.2% occurred in ART naïve patients, 17.3% in ART‐experienced patients and 49.5% in patients on ART, of whom 23% for more than 6 months. Among these patients, 24 (11.5%) had HIV‐pVL ≤50 cp/mL, and 16 (66%) were treated with a boosted‐PI‐based regimen. The distribution of KS localization did not differ by ART status nor by year of diagnosis.LimitationsData on human herpesvirus 8, treatment modalities for KS and response rate were not collected.ConclusionHalf of KS cases observed in the study period occurred in patients not on ART, reflecting the persistence of late HIV diagnosis. Factors associated with KS in patients on ART with HIV‐pVL ≤50 cp/mL remain to be explored.

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