Abstract
OBJECTIVE: To evaluate if the number of oocytes retrieved could impact on number of top quality embryo (TQ) and implantation rates (IR) in high responders patients, using ovum donation (DO) to embryo recipients (ER) as a model of validation. DESIGN: Retrospective study. MATERIALS AND METHODS: Records of all patients enrolled in the DO program at Huntington Medicina Reprodutiva between 01/08 and 04/09 were reviewed. Ovarian stimulation was accomplished either with urinary or recombinant FSH (150-300 IU/day) under GnRH agonists or antagonist. OD were divided in 2 groups, those with > than 20 eggs (group 1) and < 20 (group 2). Recipients received estradiol valerate followed by vaginal micronized progesterone to prepare the uterus for embryo transfer. IR, pregnancy rates (PR) and live births (LB) of ER were compared according to the number of oocytes harvested in their respective OD group. OD and ER age, occurrence of polycystic ovary syndrome (PCOS) and ovarian hyperstimulation syndrome (OHSS), endometrial thickness and number of embryos transferred (ET) were also recorded. Data were analyzed according Mann-Whitney, T-Test and Fisher when applicable. RESULTS: 76 ER received oocytes from 40 OD. 41 ER received oocytes from group 1 and 35 received from group 2. ER from groups 1 and 2 had similar TQ (1.64±1.75 vs. 1.23±1.45, p=.29), IR (0.26±0.31 vs. 0.29±0.33, p=.76), PR (0.64 vs. 0.7, p=.79) and LB rates (0.6 vs. 0.4, p=.31). Also OD age (26.6 ± 4.65 vs. 25.8 ± 4 years, p= .46), ER age (40.8 ±4.1vs. 41.8 ± 4.1 years, p= .31), median ER endometrial thickness (9 vs 9.3 mm, p=.65) and #ETs (3±1.2 vs. 3±0.8, p .7). Although PCOS (0.35 vs. 0.07, p= .008) and OHSS (0.47 vs. 0.17, p=.008) were significantly more common in group 1, there were no differences in overall results. CONCLUSIONS: Although OD with more than 20 oocytes were more associated with PCOS, possibly affecting oocyte quality in recipients, the embryo quality, IR and LB had similar results from donors with less than 20 oocytes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
