Abstract
We would like to thank Yarema et al for their study comparing the effects of oral and intravenous (IV) N-acetylcysteine for the treatment of acetaminophen-induced hepatotoxicity.1 This study compared data from a US multi-center group and a Canadian group suggesting that IV N-acetylcysteine may be superior up until 12 hours following acetaminophen overdose, and then both oral and IV are about equally efficacious until 18 hours when the data on oral N-acetylcysteine from the US study shows superiority.
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