Abstract
IUGR, lipid peroxidation, and calcium ATPase activity of maternal red blood cell ghosts
Highlights
Normal fetal growth depends on several components: genetic growth potential of the fetus, ability of the placenta to transfer oxygen and nutrients, as well as capacity of the mother to deliver them to the placenta
Osmotic fragility of the red cells, as well as lipid peroxidation (TBARS and conjugated dienes) and Ca-ATPase activity of their membranes were determined. It was found a higher level of osmotic fragility and lipid peroxidation, as well as a lower Ca-ATPase activity of red blood cells from the pregnant women with Intrauterine growth restriction (IUGR), as compared to control pregnant women
There is a clear relationship between IUGR and higher levels of osmotic fragility and lipid peroxidation, as well as a lower Ca-ATPase activity of red blood cells
Summary
Normal fetal growth depends on several components: genetic growth potential of the fetus, ability of the placenta to transfer oxygen and nutrients, as well as capacity of the mother to deliver them to the placenta. Intrauterine growth restriction (IUGR) is defined as an estimated fetal weight at one point in time during pregnancy being at or below the 10th percentile for gestational age, and can be regarded as a failure of the fetus to reach his genetic growth potential. It is one of the major complications of pregnancy and it is associated with increased levels of morbidity and mortality in the neonate, as well as with several disorders including obesity, diabetes and heart disease in their adulthood. Other authors have shown increased levels of lipid peroxidation (TBARS, conjugated dienes and lipid peroxides) and decreased antioxidant capacity in serum of pregnant women with IUGR [6]
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