Abstract
Background: Colon adenocarcinoma (COAD) is a common digestive system tumor in the world. However, the role and function of ISYNA1 (inositol-3-phosphate synthase 1) in COAD remain unclear. We aim to explore the role of ISYNA1 in pan-cancer, especially in COAD. Methods: The expression, clinical characteristic, and prognosis of ISYNA1 in pan-cancer were evaluated using the TCGA (the Cancer Genome Atlas), GTEx (the Genotype-Tissue Expression), and CCLE (Cancer Cell Line Encyclopedia). Pathway enrichment analysis of ISYNA1 was conducted using the R package “clusterProfiler.” We analyzed the correlation between the immune cell infiltration level and ISYNA1 expression using two sources of immune cell infiltration data, including the TIMER online database and ImmuCellAI database. Results: ISYNA1 was highly expressed in COAD and other cancer types compared with respective normal tissues. High ISYNA1 expression predicted poorer survival in COAD. We also found that ISYNA1 expression was positively correlated with the infiltration level of tumor-associated macrophages and tumor-associated fibroblasts in COAD. Conclusion: In conclusion, our findings revealed ISYNA1 to be a potential prognostic biomarker in COAD. High ISYNA1 expression indicates the immunosuppressive microenvironment.
Highlights
Colon adenocarcinoma (COAD) is a global common gastrointestinal tumor, which presents a fatal factor to the health of humans (Wei et al, 2020)
We found that ISYNA1 was highly expressed in 12 among 33 cancers types, including BLCA, BRCA, CHOL, COAD, ESCA, GBM, HNSC, liver hepatocellular carcinoma (LIHC), LUAD, LUSC, STAD, and THCA
To evaluate the expression of ISYNA1 only in tumor tissues from the Cancer Genome Atlas (TCGA) cohort, we found that ISYNA1 expression was highest in tumor tissues of UCS and lowest in tumor tissues of COAD compared with other tumor tissues (Figure 1B)
Summary
Colon adenocarcinoma (COAD) is a global common gastrointestinal tumor, which presents a fatal factor to the health of humans (Wei et al, 2020). It is pressing to explore the potential mechanisms and identify crucial biomarkers for diagnosis, prognosis, and treatment in COAD. A body of work have found that the tumor microenvironment (TME), especially the tumor immune microenvironment (TIME), plays an important role in the development of COAD and weakens the response of COAD patients for treatment (Lin et al, 2020). Colon adenocarcinoma (COAD) is a common digestive system tumor in the world. The role and function of ISYNA1 (inositol-3-phosphate synthase 1) in COAD remain unclear. We aim to explore the role of ISYNA1 in pan-cancer, especially in COAD
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