Abstract
Calcium overload induced by chronic administration of the β-adrenoreceptor agonist, isoproterenol (IP), is used in animal to study the mechanisms of cardiac hypertrophy and failure associated with a sustained increase in circulating catecholamines.
Highlights
Calcium overload induced by chronic administration of the b-adrenoreceptor agonist, isoproterenol (IP), is used in animal to study the mechanisms of cardiac hypertrophy and failure associated with a sustained increase in circulating catecholamines
Energy metabolism and nitric oxide (NO) pathway were evaluated in isolated perfused rat hearts following 7 days of treatment
MDA content was higher in IsoP (p
Summary
Calcium overload induced by chronic administration of the b-adrenoreceptor agonist, isoproterenol (IP), is used in animal to study the mechanisms of cardiac hypertrophy and failure associated with a sustained increase in circulating catecholamines. Purpose Time-dependent changes in myocardial perfusion, morphologic and functional parameters were assessed in rats in vivo using cardiac MRI. Energy metabolism and nitric oxide (NO) pathway were evaluated in isolated perfused rat hearts following 7 days of treatment
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