Abstract
Tuberculosis is one of the dangerous infectious diseases, killing over a million people worldwide each year. The search for new dosage forms for the treatment of drug-resistant tuberculosis is an actual task. Biocompatible polymer nanoparticles, in particular bovine serum albumin (BSA), are promising drug carriers. Nanoparticle (NP) parameters such as diameter, polydispersity, bioactive substance loading, and NP yield are very important when it comes to drug transport through the bloodstream. The most well-known and widely used first-line anti-tuberculosis drug, isoniazid (INH), is being used as a drug. BSA-INH NPs were obtained by an ethanol desolvation of an aqueous protein solution in the drug presence. The peculiarity of the method is that natural components, namely urea and cysteine, are used for the stabilization of BSA-INH NPs after desolvation. The characteristics of the obtained BSA-INH NPs are significantly affected by the concentration of protein, isoniazid, urea, and cysteine in the solution. The aim of the present study is to investigate the concentration effect of the system reacting components on the parameters of the NPs that are obtained. We have chosen the concentrations of four reacting components, i.e., BSA, isoniazid, urea, and cysteine, as controlling factors and applied the Taguchi method to analyze which concentration of each component has an important effect on BSA-INH NPs characteristics.
Highlights
For thousands of years, humanity has been haunted by a dangerous disease called tuberculosis
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (MTB) [1]
Tuberculosis re-emerged in Western Europe with the advent of HIV advent
Summary
Humanity has been haunted by a dangerous disease called tuberculosis. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (MTB) [1]. This disease usually affects the lungs, but it can affect other organs and systems. The World Health Organization (WHO) estimates that 10 million people became ill with and ~1.4 million died from tuberculosis in 2019 [3]. Tuberculosis patients are among the most vulnerable groups of the population because their lungs are affected, and their immune system is weakened. With COVID-19 disease, such patients have a high chance of developing lung failure and death [6]
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