Abstract
Senecavirus A (SVA), an emerging swine picornavirus of swine, is one of the causative agents of vesicular disease which is clinically indistinguishable from foot-and-mouth disease in pigs. Here, 3 cases of vesicular disease were reported which was caused by SVA in November 2018 in Henan, China. Three new SVA strains were identified and conducted a genetically evolutionary analysis. The isolates shared 98.1–99.0% genomic pairwise identity to each other and had the highest similarity, of 98.3–98.7%, with the American strain KS15-01, respectively. Phylogenetic analysis indicated that the Chinese prevalent strains could be clearly divided into cluster 1, cluster 2, and cluster 3. Furthermore, one isolate (HeNNY-1/2018) and two previously reported strains (HB-CH-2016 and SVA/CHN/10/2017) were identified as recombinants using several algorithms. It revealed that the recombination among SVA strains has occurred in China since 2016 or earlier. The findings of studies updated the prevalent status of SVA in China. Besides, the genetic evolution and recombinant events of SVA should be attracted more attentions in the future.
Highlights
Senecavirus A (SVA), known as Seneca Valley virus (SVV), is the only member of the genus Senecavirus in the family Picornaviridae [1]
The vesicular disease caused by SVA is clinically indistinguishable from foot-and-mouth disease virus (FMDV), vesicular stomatitis virus (VSV), and swine vesicular disease virus (SVDV) [2, 8]
SVA was diagnosed as the causative agent and FMDV, VSV, and SVDV were ruled out by RT-PCR tests
Summary
Senecavirus A (SVA), known as Seneca Valley virus (SVV), is the only member of the genus Senecavirus in the family Picornaviridae [1]. The vesicular disease caused by SVA is clinically indistinguishable from foot-and-mouth disease virus (FMDV), vesicular stomatitis virus (VSV), and swine vesicular disease virus (SVDV) [2, 8]. This virus has been reported in Canada, China, Colombia, Thailand, Viet Nam, and elsewhere, suggesting that SVA-induced disease has already become a worldwide problem [7, 10,11,12]. In China, the vesicular disease caused by SVA was first reported in Guangdong province in 2015 [12]. We report 3 apparently unrelated cases of vesicular disease in November 2018 in Henan province, China. One of the isolates and two strains reported before were all identified as recombinants with unique recombination patterns
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
