Abstract
Adult bone marrow is the site of intense hematopoietic activity that is housed in a unique connective tissue called bone marrow stroma. The stroma establishes a niche in which specific hematopoietic lineage pathways are managed in proximity to a rich vascular network. The bone and its osteoblasts, osteoclasts, and “resting cells” are also contributors to this microenvironment. Also present within this mix of cells are rare multipotent cells that can differentiate along several mesenchymal lineage pathways, culminating in the formation of bone, cartilage, muscle, marrow stroma, tendon and ligament, fat, and other connective tissues.
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