Abstract
Schistosomiasis is a neglected tropical disease caused by helminth flatworms of the genus Schistosoma. Currently, praziquantel is the only medication available. Schistosomiasis is the second most deadly parasitic infection after malaria. Dolichos pachyrhizus's (Fabaceae) rhizome is commonly utilized as an antihelmintic. In this study, the in vitro antischistosomal activity of D. pachyrhizus crude extract and isolated compounds were examined against S. mansoni immature worms. All mature and immature worms were killed by C1, C2 and ethyl acetate extract at 500 mg/mL after 24 h incubation. Additionally, all the examined compounds and extract at 500 mg/mL exponentially reduced the parasite's movement; (70-90 %) shrinkage, viability (10-30 %) and mortality (70-90 %) rates.
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