Abstract
A method is described for the isolation of immune complexes (IC) employing polyethylene glycol (PEG) precipitation and competitive binding to staphylococcal protein A (Staph A). Techniques for recovery of IC from Staph A were established using preformed IC of BSA anti-BSA . Studies in patients with hepatitis B systemic vasculitis revealed elevated levels of IC in serum, but levels did not correlate closely with disease activity. Analysis of IC in serum revealed both HBsAg and anti-HBs, whereas anti-HBs was not detectable in whole serum. The methodology described may have important application to immune complex diseases in which the inciting antigen is not known.
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