Abstract
Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh2(OCOCF3)4] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7.
Highlights
Fungi which are rich sources of bioactive natural products have played an important role in discovery of lead compounds for therapeutics [1]
17 from the extract were identified as inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone crude extract were identified as inflatin
Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed Rh2 (OCOCF3 )4 complexes
Summary
Fungi which are rich sources of bioactive natural products have played an important role in discovery of lead compounds for therapeutics [1]. On the basis of this consideration and the documented success in finding new bioactive natural products from special types of fungi [4], we initiated chemical studies of the Cordyceps-colonizing fungi [5] and those that were isolated from the soil samples surrounding Cordyceps sinensis [6]. The ascomycetous fungus T. inflatum (SCK6-CP14) was isolated from a soil sample on the surface of C. sinensis collected in Kangding, Sichuan, People’s Republic of China. Our prior investigations of T. inflatum grown in solid-substrate fermentation cultures have resulted in the isolation of structurally diverse and biologically active metabolites, such as the aphidicolin and chlamydosporol derivatives [6].
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