Abstract
OBJECTIVE:In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated.METHOD:DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction–restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method.RESULT:At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study.CONCLUSION:There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.
Highlights
Osteoporosis is a disease that causes general health problems associated with low bone mass and microarchitectural damage in bone tissue
A total of 150 female patients with postmenopausal osteoporosis were included in the study to investigate the relationship between postosteoporotic spinal fractures and the distribution of 9041 G/A and 3673 G/A polymorphisms in the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene
There was no relationship between the VKORC1 9041 G/A polymorphism and allele frequency in patients with and without postmenopausal osteoporosis (p=0.283, p=0.221)
Summary
Osteoporosis is a disease that causes general health problems associated with low bone mass and microarchitectural damage in bone tissue These changes in bone structure cause increased bone fragility and fracture susceptibility [1]. The increased prevalence of osteoporosis-associated fractures with increased life span has resulted in lower quality of life, disability and even death [2]. Received for publication on April 10, 2018. Accepted for publication on November 28, 2018
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