Abstract
The kidney responds to variations in the supply of inorganic phosphate (Pi) by changing its tubular capacity to transport Pi (1,2,3). This change represents very likely a homeostatic response which tends to adjust the rate of Pi excretion according to the needs of the organism. It would be logical to envisage that, according to this concept, variations in the needs of Pi should also lead to a homeostatic adjustment in the rate of tubular Pi transport. In the growing animals a large portion of the ingested Pi is taken up by the skeleton for mineralization. A decrease in the capacity of the bone to retain calcium and phosphate therefore should elicit a change in the renal handling of Pi similar to that promoted by an increment in the dietary Pi supply.KeywordsOrganic PhosphateRenal HandlingPhosphate HomeostasisHomeostatic ResponseRenal Phosphate ReabsorptionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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