Abstract
1. When histamine and beef-broth were used as gastric secretory stimulants, the range in the acidities were the same in both the treated and untreated Mann-Williamson dogs. The Mann-Williamson dogs that benefited by treatment (that lived longer than the maximum survival time of our control dogs—as long as two and three years following the operation) showed approximately the same concentration of acid as did our control (untreated) dogs. It therefore appears that the prophylactic and therapeutic effect against Mann-Williamson ulcers obtained with the extracts from urine of pregnant and normal women was not due to the inhibition of acid by the gastric secretory depressant in urine. 2. Apparently pregnancy urine extracts and normal female urine extracts exert a beneficial effect through stimulation of active fibroblastic proliferation and epithelialization of the ulcer. This process can occur in the presence of an unaltered gastric acid juice. Apparently pregnancy urine extracts and normal female urine extracts exert a beneficial effect through stimulation of active fibroblastic proliferation and epithelialization of the ulcer. This process can occur in the presence of an unaltered gastric acid juice.
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