Is it connection between systemic inflammation and risk of thrombotic disorders (by Padua scale) in hospitalized patients with community-acquired pneumonia (CAP)?

Abstract

Risk factors of mortality in severe CAP including lung vessels thrombosis did not investigated to the end. Aim: to study the correlation between severity of systemic inflammation (levels of C-reactive protein (CRP) and procalcitonin (PCT)) and level of thrombosis risk (scores by Padua scale) in patients with moderate and severe CAP. Methods: main group – 66 patients (age – 56.0 [37.0-61.0] years old, men – 39 (63.9%)) (38 pts with moderate CAP, 28 pts with severe CAP). Results: the mean level of Padua scale in patients with CAP was 3,76 [2,0-6,0], which showed very high risk of thrombosis. The level of CRP was 155.9 [95.9-297.3] mg/l, PCT – 1.04 [0.7-12.1] ng/ml. We found significant correlation between: Padua scale and CRP (R=0,230, p Autopsy of patients with severe CAP found thrombosis of small or/and large branches of the pulmonary artery. Conclusions: 1. Patients with moderate and severe CAP are characterized by very high risk of thrombosis by Padua scale. 2. Increased levels of CRP and PCT are correlated with high risk of lung vessels thrombosis and show the direct connection between systemic inflammation and thrombotic disorders in patients with moderate to severe CAP.