Abstract
Hematopoietic stem cell transplantation (HSCT) outcome has improved dramatically since the introduction of allele level HLA typing. Currently, HLA laboratories are using three different technologies for allele level matching, PCR amplification with sequence-specific primers (PCR-SSP), polymerase chain reaction-sequence-specific oligonucleotide probes (SSOP), and sequence-based typing (SBT). However, it is important to emphasize that SBT is the only HLA typing method so far that allows scrutiny of every nucleotide in the HLA gene sequence, therefore, it allows us to recognize new alleles and potential gene mutations that would ensure allele level typing to be as good as claimed.
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