Abstract
| 223 diabetic with proliferative diabetic retinopathy (PDR). Ox-LDL and IgG/M was absent in non-diabetic subjects but present in all three diabetic groups, increasing with severity of DR. Merged images revealed co-localization of ox-LDL and IgG/M. In cell culture studies, induction of apoptosis by human LDL-IC in human retinal capillary pericytes (HRCP) was assessed. Human LDL-IC (50 mg/L) significantly attenuated viability in HRCP at 6 and 24 hrs. In contrast, rabbit LDLIC and ox-LDL (50 mg/L) did not induce this effect (however ox-LDL also triggered apoptosis, but at higher concentrations). The apoptotic mechanisms were related to PARP pathways and caspase cascade activation. The data suggest a potentially important role for LDLIC, formed after extravasation and oxidation of LDL in the retina, in promoting an early feature of DR, pericyte loss by apoptosis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
