Abstract

EVIDENCE-BASED ANSWER Combination therapy with an alpha-blocker and dihydrotestosterone (DHT) blocker is superior to either agent alone for reducing clinical progression of BPH and symptom deterioration. Combination therapy is inconsistently better than alpha-blockers for reducing acute urinary retention and in need for invasive therapy, but combination therapy causes a few more adverse events than either monotherapy (SOR: A, 2 RCTs).

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