Abstract
Iron oxide nanoparticles (IONPs) with intrinsic peroxidase-like activity were proven to be effective and direct catalyst of the nanogelation of synthetic polypeptide precursor poly[N5-(2-hydroxypropyl)-L-glutamine-ran-N5-propragyl-L-glutamine-ran-N5-(6-aminohexyl)-L-glutamine]-ran-N5-[2-(4-hydroxyphenyl)ethyl)-L-glutamine] (P2HPG). IONPs catalytic activity and kinetics were determined to mimic the horseradish peroxidase (HRP) used in the nanogelation of the polymer precursor containing a phenol moiety. The prepared nanogels were characterized by dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), and (cryogenic) transmission electron microscopy (cryo-TEM/TEM). Smart IONPs-catalyzed nanogelation resulted in soft and spherical nanoparticles with diameter of approximately 80 nm.
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