Abstract
Iron is involved in different processes which seem to be unrelated to each other: metabolic pathways, cell cycle, radical production, and apoptosis. However, all these processes are interrelated by flow of signals in cells and communication among cells and organs. Consequently, an intervention with an iron chelator has direct and indirect effects on various cell functions and should be carefully examined before being applied. In plasmodial infections, there are additional complications which make it even more difficult to discriminate individual effects of iron chelation. The approach of developing an iron chelator for treatment of malaria, based on a temporary effect on parasitemia, is naive.
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