Abstract
Editorial FocusIron chelation therapy to prevent poststroke cognitive impairments: role of diabetes and sexSiva S. V. P. Sakamuri, Venkata N. Sure, and Prasad V. G. KatakamSiva S. V. P. SakamuriDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, Venkata N. SureDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, and Prasad V. G. KatakamDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LouisianaNeuroscience Program, Tulane Brain Institute, Tulane University, New Orleans, LouisianaClinical Neuroscience Research Center, Tulane University, New Orleans, LouisianaPublished Online:17 Jan 2023https://doi.org/10.1152/ajpheart.00004.2023This is the final version - click for previous versionMoreSectionsFull TextPDF (246 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat "Iron chelation therapy to prevent poststroke cognitive impairments: role of diabetes and sex." American Journal of Physiology-Heart and Circulatory Physiology, 324(2), pp. H210–H211REFERENCES1. Maida CD, Daidone M, Pacinella G, Norrito RL, Pinto A, Tuttolomondo A. Diabetes and ischemic stroke: an old and new relationship an overview of the close interaction between these diseases. Int J Mol Sci 23: 2397, 2022. doi:10.3390/ijms23042397.Crossref | PubMed | ISI | Google Scholar2. Spronk E, Sykes G, Falcione S, Munsterman D, Joy T, Kamtchum-Tatuene J, Jickling GC. Hemorrhagic transformation in ischemic stroke and the role of inflammation. Front Neurol 12: 661955, 2021. doi:10.3389/fneur.2021.661955.Crossref | PubMed | ISI | Google Scholar3. Fang XL, Ding SY, Du XZ, Wang JH, Li XL. Ferroptosis-a novel mechanism with multifaceted actions on stroke. Front Neurol 13: 881809, 2022. doi:10.3389/fneur.2022.881809. Crossref | PubMed | ISI | Google Scholar4. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149: 1060–1072, 2012. doi:10.1016/j.cell.2012.03.042. Crossref | PubMed | ISI | Google Scholar5. Abdul Y, Li W, Ward R, Abdelsaid M, Hafez S, Dong G, Jamil S, Wolf V, Johnson MH, Fagan SC, Ergul A. Deferoxamine treatment prevents post-stroke vasoregression and neurovascular unit remodeling leading to improved functional outcomes in type 2 male diabetic rats: role of endothelial ferroptosis. Transl Stroke Res 12: 615–630, 2021. doi:10.1007/s12975-020-00844-7. Crossref | PubMed | ISI | Google Scholar6. Li W, Valenzuela JP, Ward R, Abdelbary M, Dong G, Fagan SC, Ergul A. Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation. Exp Neurol 311: 106–114, 2019. doi:10.1016/j.expneurol.2018.09.013. Crossref | PubMed | ISI | Google Scholar7. Bushnell CD, Chaturvedi S, Gage KR, Herson PS, Hurn PD, Jiménez MC, Kittner SJ, Madsen TE, McCullough LD, McDermott M, Reeves MJ, Rundek T. Sex differences in stroke: challenges and opportunities. J Cereb Blood Flow Metab 38: 2179–2191, 2018. doi:10.1177/0271678X18793324. Crossref | PubMed | ISI | Google Scholar8. Banerjee A, McCullough LD. Sex-specific immune responses in stroke. Stroke 53: 1449–1459, 2022. doi:10.1161/STROKEAHA.122.036945. Crossref | PubMed | ISI | Google Scholar9. Li W, Ward R, Valenzuela JP, Dong G, Fagan SC, Ergul A. Diabetes worsens functional outcomes in young female rats: comparison of stroke models, tissue plasminogen activator effects, and sexes. Transl Stroke Res 8: 429–439, 2017. doi:10.1007/s12975-017-0525-7.Crossref | PubMed | ISI | Google Scholar10. Li W, Abdul Y, Chandran R, Jamil S, Ward RA, Abdelsaid M, Dong G, Fagan SC, Ergul A. Deferoxamine prevents post-stroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis. Am J Physiol Heart Circ Physiol 324: TBA, 2023. doi:10.1152/ajpheart.00490.2022.Link | Google Scholar Back to Top Next Download PDF FiguresReferencesRelatedInformation Related ArticlesDeferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis 17 Jan 2023American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 324Issue 2February 2023Pages H210-H211 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/ajpheart.00004.2023PubMed36607799History Received 4 January 2023 Accepted 5 January 2023 Published online 17 January 2023 Published in print 1 February 2023 Keywordscognitiveferroptosismicrogliamicrovascularneurovascular Metrics
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