Abstract
Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.
Highlights
Hepatic fibrosis resulted from chronic liver injury induced by viral attack, autoimmune responses, drug-induced problems, cholestatic and metabolic diseases is a wound-healing response in which various cytokines and molecules would activate hepatic stellate cells (HSCs) and undergo transformation from quiescent cells into fibrogenic cells [1–8]
Induction of activated HSCs apoptosis has been proposed as a potential anti-fibrotic strategy [11–13]
Emerging scientific evidences have suggested that traditional Chinese herbs are efficacious for treating chronic liver diseases due to their multi-ingredients, multi-mechanism of actions, and low adverse effects characteristics [14]
Summary
Hepatic fibrosis resulted from chronic liver injury induced by viral attack, autoimmune responses, drug-induced problems, cholestatic and metabolic diseases is a wound-healing response in which various cytokines and molecules would activate hepatic stellate cells (HSCs) and undergo transformation from quiescent cells into fibrogenic cells [1–8]. HInz,thHe-7H),ManBdC6.s4p0e(c1tHru, md, Jo=f 126, .t0hHerze, Hw-e8r)ec2oJ,u3lJd-cboerrfeoluatniodnisnf2r.oImn tChHe 3H-1M4 BaCndspCeHct3r-u15mtoofC2-,1t,hCer-e2,waenrde C2J-,63;Jf-rcoomrreClaHti2o-n12s ftroomC-9C,HC3--1104, aanndd CCH-131-;1f5rotomCH-1-,4Cto-2C, a-5ndanCd-6C; -f1ro3m; frCoHm2H-1-27ttooCC-9-8, Can-1d0,Ca-n9d; fCro-m11;Hfr-o8mtoHC--46,toCC-7-,5Ca-n9d, aCn-d13C; -f1ro2m; frHom-7 tHo-C10-8taonCd-C11-9a; nfrdomC-H12-8; atondC-f6r,oCm-7H, C-1-93, taondCC-4-1a2n;dfroCm-6Hre-1s0petoctCiv-e1l1y.anTdheCs-e12s;paencdtrafrlocmhaHra-1ct3etroisCtic-4s ainnddicCa-t6edretshpaetct2ivieslya. IanndthCe-H12M; aBnCd sfproecmtruHm-1o3f′b3,ttoheCre-4w′,eCre-52J′, a3nJ-dcoCrr-e1la1t,iorensspferoctmivCelHy.3-I1n4 aandddiCtiHon3,-1t5hteoreC-w1,eCre-22,Ja, n3dJ-cCo-r6r;eflraotmionCsHf3r-o1m2 tCoHC3--81,4C′ -a9n,danCdHC3--1150′; ftrooCm-1H′,-4C-t2o′,Ca-n13d; Cfr-o6m′; fHro-6mtoCCH-31-,1C2′-5to, CC--78,′,anCd-9C′,-a8n; fdroCm-1H0′;-7frtoomC-H9;-6fr′otmo CH--18′, tCo-C7′-,6a, nCd-1C0,-a8n′;dfrCo-m12H; f-r7o′mtoHC-1-09′t;ofrCo-m8 aHnd-8C′ t-o12C; a-6n′d, Cfr-o1m0′,Han-1d31Cb -t1o2C′; -f4r1o, mC-5H1 -a1n0d′ tCo-1C1-,8r′easpnedctCiv-1el2y′., Irnesapdedcittivioenly, .thTehree w3J-eHreM2BJ,C3Jc-ocorrrerlealtaitoinonfsrofrmomH-C1H3′a3-1a4n1danHd-1C3H′b3t-o15C1 t-o11C(-δ111, 6C7-.211), danetderCm-6in1;edfrotmhe CliHnk3a-1g2e1 otof dCi-m81e, rCt-o91b, eanthdrCou-1g0h1;ofxroymgeHn -a6t1otmo Cbe-1tw[1], Cee-n71,Ca-n11d aCn-d81;Cf-r1o3m′. Inhibitory effects of P. linteus (PLE) and phellinulin A (1) on activated rat hepatic stellate. Tcaeblllse(H1.SICnsh).ibitory effects of P. linteus (PLE) and phellinulin A (1) on activated rat hepatic stellate cells (HSCs).
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