Abstract
ContextBariatric surgery can lead to nutrient deficiencies. Gastric by-pass (GBP) entails restriction and malabsorption, whereas, vertical banded gastroplasty (VBG) is only restrictive.ObjectiveThe objective of this study is to study whether GBP-patients develop iodine deficiency from malabsorption, and if GBP- and VBG-patients develop lower 24-h urinary iodine excretion (24-UIE) than obese non-operated controls (OB-controls) due to lower iodine intake.DesignThe Swedish Obese Subjects (SOS) study is a prospective, non-randomized study of 4047 obese patients included 1987–2001, who chose bariatric surgery or non-surgical treatment. SOS-groups were compared at baseline, after 2 and 10 years and with population-based subsamples (MONICA-controls).PatientsOne hundred eighty-eight GBP-patients were matched with 188 VBG-patients and 188 OB-controls and with three subgroups from 412 MONICA-controls.Main Outcome MeasurementsPrimary outcome was 24-UIE. Secondary outcomes were iodine intake, iodine supplementation, TSH, FT4, and thyroid morbidity.ResultsAt baseline, median 24-UIE was higher in GBP-patients, VBG-patients and OB-controls than in MONICA-controls (214, 201, 203 and 137 μg/day, p < 0.001). At 10 years, 24-UIE in GBP-patients (161 μg/day) and VBG-patients (149 μg/day) was lower compared with baseline (p < 0.01) and OB-controls (189 μg/day, p < 0.01), but similar to 24-UIE in MONICA-controls (137 μg/day). The 10-year-dietary iodine intake was similar in GPB-patients and OB-controls, but higher in VBG-patients. Iodine supplementation was taken by 0–9% in SOS-groups.ConclusionAfter surgery, GBP- and VBG-patients did not suffer from iodine deficiency, but both groups had lower iodine status than OB-controls. Dietary supplements recommended after bariatric surgery do not need to include iodine, in iodine sufficient countries.Trial Registrationclinicaltrials.gov: NCT01479452
Highlights
Bariatric surgery is increasingly used [1, 2] and can lead to several nutrient deficiencies [3]
At baseline, median 24-h urinary iodine excretion (24-UIE) was higher in Gastric by-pass (GBP)-patients, Vertical banded gastroplasty (VBG)-patients and OB-controls than in MONICAcontrols (214, 201, 203 and 137 μg/day, p < 0.001)
At 10 years, 24-UIE in GBP-patients (161 μg/day) and VBGpatients (149 μg/day) was lower compared with baseline (p < 0.01) and OB-controls (189 μg/day, p < 0.01), but similar to 24-UIE in MONICA-controls (137 μg/day)
Summary
Bariatric surgery is increasingly used [1, 2] and can lead to several nutrient deficiencies [3]. The hypothesis on iodine deficiency after bariatric surgery was generated from a study in 1964 [4]. Bariatric surgery procedures are either restrictive, malabsorptive, or a combination thereof. Vertical banded gastroplasty (VBG) is a restrictive surgery, no longer performed, where a stomach pouch is created, but the intestine remains intact [5]. Gastric by-pass (GBP) is a widely performed combined technique, where a gastric pouch is created. Regardless of the type of surgery, patients may have altered food preferences or vomiting problems [6, 8]; both iodine intake and uptake may be influenced
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