Abstract
AbstractIodination and O‐arylation of 2‐arylquinolin‐4(1H)‐one with PIDA under mild conditions have been developed, in which PIDA play a dual role as an iodine source and an aryl source. This protocol provides a facile access to 3‐iodo‐4‐phenoxy‐2‐arylquinolines with tolerance of a broad range of functional groups. Furthermore, This method is employed for concise synthesis of topoisomerases catalytic inhibitor analogue.
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