Abstract
The effect of the benzodiazepine receptor antagonist flumazenil was examined on an antiaggressive effect of ( S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3- benzodioxole HCl (MKC-242), a 5-HT 1A receptor agonist. MKC-242 (0.1–1.0 mg/kg, p.o.) selectively reduced isolation-induced aggressive behavior in a dose-dependent manner. Flumazenil (10 mg/kg, i.p.) antagonized the antiaggressive effects of MKC-242 and diazepam, although it alone did not affect the behaviors of isolated mice. These findings suggest that a γ-aminobutyric acid A (GABA A) receptor system is involved in the antiaggressive effect by 5-HT 1A receptor activation.
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