Abstract
Synchrotron radiation (SR) micro beams were used to investigate ultra‐trace elements in a single cell. X‐ray fluorescence (XRF) spectroscopy using SR was applied to determine the distribution and density of the ultra‐trace elements in incubated prostate cancer cells. Metallic elements such as zinc, iron and copper play an important role in the metabolism and regulatory dynamics of cells. In this study, we focused on zinc because the prostate tissues contain the highest levels of zinc compared to any other tissues in the body and the level of zinc is a factor that influences the progress of malignancy. We measured two types of cells (LNCaP and C4‐2) that were incubated in the normal culture medium, zinc‐contained one or testosterone‐contained one. The distribution and density of zinc, calcium, copper and iron have close relations to the existence of zinc and androgen in the culture medium.
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