Investigations of gold nanoparticles-mediated carbon nanotube reinforced hydroxyapatite composite for bone regenerations

Abstract

An excellent combination of biomaterials permits prompt features and high-throughput investigations in various fields, particularly in the biomedical applications. This article investigates the bone regeneration ability and compatibility of the Gold (Au) Nanoparticles (NPs) medicated carbon nanotube reinforced hydroxyapatite (HAP) composite. The morphologies of the synthesized Au NPs, HAP and HAP/CNT, and HAP/CNT-Au composites vary suggestively with modifying the components and the final composite showing as bone mimic extracellular matrix morphology. The structure, phase, and composition of the as-synthesized HAP were studied by FTIR, XRD, EDAX, and TEM techniques. The materials' biocompatibility was investigated in the Stimulated Body Fluid (SBF) solution, which resulted in the composite having good biocompatibility, bioactivity nature and hydroxyapatite layer formed on the composite surface. The composite shows good viability with Adipose Tissue-derived Stem Cells (ADSC) to cell growth and cell proliferation in the biological evaluation. It represented the composites having a good ability for cell formation development. Since the HAP/CNT-Au composite are useful in medicinal applications such as orthopedic and orthodontic repair/regenerations after the evaluations of animal and clinical investigations.