Abstract
Single nucleotide polymorphisms (SNPs) in energy metabolism related gene may be key agents in the development of human malignancies. In this study, we aimed to examine the association of transcription factor 7-like 2, Leptin (LEP) and LEP receptor (LEPR) polymorphisms with esophageal squamous cell carcinoma (ESCC). A total of 507 ESCC cases and 1,496 controls were enrolled. We found that LEPR rs6588147 AA genotype was associated with ESCC risk (AA vs. GG/GA: adjusted OR=1.90, 95%CI=1.00–3.61, P=0.049). In the stratified analyses, LEPR rs6588147 G>A polymorphism increased the risk of ESCC (<63 years subgroup: AA vs. GG: adjusted OR=2.58, 95%CI=1.00–6.62, P=0.049 and AA vs. GA/GG: adjusted OR=2.71, 95%CI=1.06–6.91, P=0.038; male subgroup: AA vs. GG: adjusted OR=2.19, 95%CI=1.02–4.67, P=0.044 and AA vs. GA/GG: adjusted OR=2.26, 95%CI=1.06–4.80, P=0.035). However, LEP rs7799039 A>G decreased the risk of ESCC (≥63 years subgroup: GG vs. AA: adjusted OR=0.47, 95%CI=0.23–0.95, P=0.035 and GG vs. AA/AG: adjusted OR=0.48, 95%CI=0.24–0.96, P=0.038; BMI≥24 kg/m2 subgroup: AG vs. AA: adjusted OR=0.66, 95%CI=0.45–0.99, P=0.044). In addition, LEPR rs1137101 G>A polymorphism decreased ESCC risk in some subgroups (ever smoking subgroup: GA vs. GG: adjusted OR=0.66, 95%CI=0.44–1.00, P=0.049; ever drinking subgroup: GA vs. GG: adjusted OR=0.54, 95%CI=0.31–0.95, P=0.031 and GA/AA vs. GG: adjusted OR=0.54, 95%CI=0.31–0.93, P=0.027). Our findings suggest that LEPR rs6588147 G>A polymorphism is associated with the increased risk of ESCC; however, LEP rs7799039 A>G and LEPR rs1137101 G>A polymorphisms may be protective factors for ESCC.
Highlights
In China, esophageal cancer (EC) is the fourth most commonly diagnosed cancer in males and the fifth in females, with an estimated 477,900 new patients and 375,000 related deaths occurring in 2015 [1]
We aimed to examine the association of transcription factor 7-like 2, Leptin (LEP) and LEP receptor (LEPR) polymorphisms with esophageal squamous cell carcinoma (ESCC)
In the analysis of LEPR rs6588147 G>A polymorphism, we found significant differences in the distribution of the rs6588147 AA genotype compared with the rs6588147 GG genotype and rs6588147 AA genotype compared with the rs6588147 GA/GG genotypes between 507 Esophageal squamous cell carcinoma (ESCC) cases and 1,496 controls [AA vs. GG: crude odds ratio (OR) = 1.87, 95% confidence interval (CI) =
Summary
In China, esophageal cancer (EC) is the fourth most commonly diagnosed cancer in males and the fifth in females, with an estimated 477,900 new patients and 375,000 related deaths occurring in 2015 [1]. The contributing risk factors for ESCC are not fully known, but are thought to involve low intake of vegetables and fruits, poor nutritional status, smoking and eating and/or drinking at high temperatures. These primarily identified risk factors could not account for all the etiology of ESCC. A recent study indicated that preoperative metabolic syndrome might be an effective predictor of ESCC mortality [3].
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