Abstract
Abstract Objectives There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the TAGAP gene; however, there has been no study on Turkish pediatric patients. We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients. Methods Totally, 127 pediatric CD patients and 100 healthy children were included. We determined the polymorphism by the allele-specific polymerase chain reaction method. We used IBM SPSS Statistics version 25.0 and Arlequin 3.5.2 for the statistical analyses. The authors have no conflict of interest. Results It was determined that 72% (n=154) of only CD patients had C allele, whereas 28% (n=60) had T allele. Of the patients with celiac and T1DM, 42.5% (n=17) and 57.5% (n=23) had T and C alleles, respectively. Of the individuals in control group, 67% (n=134) had C allele, whereas 33% (n=66) had T allele. Conclusions There was no significant difference in the genotype and allele frequencies between the patient and control groups (p>0.05). There was no significant association between the disease risk and the polymorphism in our study group.
Highlights
Celiac disease (CD) is a systemic enteropathy of the small intestine of which development and symptoms are affected by environmental factors and genetic predisposition [1, 2]
There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the T-cell activation Rho GTPase activating protein (TAGAP) gene; there has been no study on Turkish pediatric patients
We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients
Summary
Celiac disease (CD) is a systemic enteropathy of the small intestine of which development and symptoms are affected by environmental factors and genetic predisposition [1, 2]. Most of the celiac patients have HLA DQB1*02 and DQA1*05 (HLA DQ2.5) allotype that presents gluten peptides to gluten-reactive CD4+ T cells in CD. It infrequently develops in the lack of HLA DQ2.5 heterodimers, and that the predisposing HLA DQ2.5 subtypes are necessary, but not competent for causing the CD [4]. The investigators have previously shown an association between CD and other autoimmune diseases. Type 1 diabetes mellitus (T1DM) is one of these autoimmune disorders, and almost 5% of CD patients have T1DM [5]. rs1738074 T/C single nucleotide polymorphism (SNP) has been found associated with CD and T1DM (p=1.7 x 10−4) [6]
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