Abstract
Leptin receptor (LEPR) signaling may be involved in promoting angiogenesis and proliferation, inhibiting apoptosis and playing a vital role in the progression of carcinogenesis. A number of studies have focused on the association of LEPR rs1137101 variants with susceptibility of cancer, however, the observed results were controversial. We searched literature on the relationship of LEPR rs1137101 G>A polymorphism with cancer risk by using PubMed and Embase databases, covering all publications up to 14 October 2018. In total, 44 case–control studies with 35,936 subjects were included. After combining all eligible studies, we identified null relationship between LEPR gene rs1137101 G>A polymorphism and overall cancer risk [A vs. G: odds ratio (OR ) = 0.97, 95% confidence interval (CI ) = 0.89–1.06, P = 0.547; AA vs. GG: OR = 0.93, 95% CI = 0.78–1.13, P = 0.476; AA/GA vs. GG: OR = 0.99, 95% CI = 0.91–1.09, P= 0.890 and AA vs. GA/GG: OR = 0.92, 95% CI = 0.82–1.04, P= 0.198]. However, in a subgroup analysis, there was an increased susceptibility of oral and oropharyngeal cancer in AA vs. GA/GG genetic model (OR, 1.83; 95% CI, 1.01–3.33; P=0.048). Considering the limited participants were included, the findings might be underpowered. Sensitivity analysis identified that any independent study omitted did not materially influence the pooled ORs and CIs. The results of publication bias detection showed that there was no evidence of bias. In summary, this analysis indicates that no significant association of cancer risk was identified to be correlated with rs1137101 G>A variants, even in stratified analyses.
Highlights
Cancer is one of the common health burden worldwide
After combining all eligible studies, we identified null relationship between Leptin receptor (LEPR) gene rs1137101 G>A polymorphism and overall cancer risk [A vs. G: odds ratio (OR) = 0.97, 95% confidence interval (CI) = 0.89–1.06, P=0.547; AA vs. GG: OR = 0.93, 95% CI = 0.78–1.13, P=0.476; AA/GA vs. GG: OR = 0.99, 95% CI = 0.91–1.09, P=0.890 and AA vs. GA/GG: OR = 0.92, 95% CI = 0.82–1.04, P=0.198]
LEPR rs1137101 G>A polymorphism is located on the exon region of LEPR gene, and it has been thought to be involved in the development of cancer by a number of studies
Summary
Cancer is one of the common health burden worldwide. Due to the prevalence of smoking and drinking, environmental pollution, as well as population aging, the incidence of malignancy is rising. The prognosis of cancer could be poorer than that in the developed countries. The reason of this phenomenon may be due to the diagnosis at an advanced stage combined with limited treatment. Some effective measures can potentially contribute to relieve the global cancer burden, including the application of precise early detection and treatment, tobacco and alcohol control, vaccine injection, sufficient fruits and vegetables intake and appropriate physical exercise. Overweight/obesity influences the health of more than 200 million people [2]. Overweight/obesity may play a vital role in growing morbidity of malignancy [3,4,5]. It is believed that overweight/obesity-related genes could affect the development of cancer
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