Abstract
A new type of normoxic polymer gel dosimeter, named MAGAT responses well to absorbed dose even when manufacturing in the presence of normal levels of oxygen. The aim of this study was to evaluate dose response, diffusion effect and cumulated dose response under multiple fractional irradiations of the MAGAT gel dosimeter using Multiple Spin-Echo (MSE) Magnetic Resonance (MR) sequence. Dose response was performed by irradiating MAGAT-gel-filled testing vials with a 6MV linear accelerator and a linear relationship was present with doses from 0 to 6Gy, but gradually, a bi-exponential function result was obtained with given doses up to 20Gy. No significant difference in dose response was present between single and cumulated doses (p>0.05). For study of diffusion effect, edge sharpness of the R2 map imaging between two split doses was smaller than 1cm of dose profile penumbra between 20% and 80%. In conclusion, the MAGAT polymer gel dosimeter with MSE MR imaging is a promising method for dose verification in clinical radiation therapy practice.
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