Abstract
Objective: Restless legs syndrome is a disorder that negatively affects quality of life. Pregnancy increases the frequency of restless leg syndrome. Symptoms that occur during pregnancy can become permanent. This study aimed to investigate the possible relationship between restless legs syndrome and biochemical parameters. Method: Alanya Alaaddin Keykubat University Education and Research Hospital was included in our randomly selected 100 pregnant women that applied to the Gynecology and Obstetrics outpatient clinic. The demographic characteristics and laboratory results of the patients were recorded. Patients were divided into two groups: one group with restless leg syndrome, and one group without. It was investigated whether there is a statistically significant difference between the demographic characteristics, blood biochemical levels, and hormonal levels between the two groups. Results: Age, height, weight, body mass index, ferritin with pregnancy week, magnesium, vitamin D, vitamin B12, thyroid stimulant hormone (TSH), hemoglobin, calcium, and aspartate aminotransferase / alanine aminotransferase (AST/ALT) levels were similar between the two groups (p>0.05). Conclusion: Restless legs syndrome is seen in about a third of the pregnancies. Pregnant patients do not come to the doctor with this complaint, because leg complaints are a normal condition caused by pregnancy. For this reason, they continue to live with symptoms of restless leg syndrome and endure this problem. However, this disease can be diagnosed with specific inquiries of physicians regarding restless leg syndrome. Although this study could establish no significant relationship between routine biochemical parameters and RLS, it is essential to examine the possible relationship in larger patient groups in terms of evidence-based medicine.
Highlights
Restless legs syndrome (RLS) is a health condition of unpleasant leg sensations that typically occurs before the onset of sleep, causing a very strong urge to move the legs [1]
Age, height, weight, body mass index, ferritin with pregnancy week, magnesium, vitamin D, vitamin B12, thyroid stimulant hormone (TSH), hemoglobin, calcium, and aspartate aminotransferase / alanine aminotransferase (AST/ALT) levels were similar between the two groups (p>0.05)
Pregnant patients do not come to the doctor with this complaint, because leg complaints are a normal condition caused by pregnancy
Summary
Restless legs syndrome (RLS) is a health condition of unpleasant leg sensations that typically occurs before the onset of sleep, causing a very strong urge to move the legs [1]. Its symptoms appear at rest, are relieved with movement, and often worsen in the evening. It was first described by Thomas Willis in 1685 in patients suffering from insomnia and restlessness in the legs. Ekbom identified RLS symptoms and described pregnancy as a cause of RLS [3,4]. Secondary RLS is associated with various conditions such as iron deficiency, diabetes, uremia, pregnancy, Parkinson’s disease, neuropathy, myelopathy, rheumatoid arthritis, and antipsychotic or antidepressant medication use [5,6]
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