Abstract
Objective: The main aim of this study was to formulate, develop and optimized a duloxetine hydrochloride (dlx-hcl) loaded mucoadhesive microemulsion intended for intranasal administration.Methods: Established on solubility studies capmul mcm, transcutol-p, labrasol were used as oil, co-surfactant and surfactant respectively. The optimized mucoadhesive microemulsion prepared using water titration method was further characterized for particle size, polydispersity index, zeta potential and conductivity measurements followed by drug content, nasal cilio toxicity and biochemical estimation of the selected formulation.Results: All physicochemical parameters conducted, proved that dlx-hcl microemulsion was appropriate for nasal delivery. Chitosan, used as mucoadhesive polymer demonstrated enhanced retention time of the microemulsion in nasal mucosa with no signs of toxicity and epithelial damage. The particle size and zeta potential were found to be of 200 nm and-15 mV respectively considering the formulation safe for nasal delivery.Conclusion: This formulation strategy can be used as an effective targeting technique for the drugs having low bioavailability and poor brain penetration along with an effective method for the treatment long-term disease like depression.
Highlights
Treatment involving site-specific delivery to the central nervous system along with prolonged presence and sustain release of a drug to attain steady-state levels is regarded as an ideal effective psychotherapy
Duloxetine showed maximum solubility in capmul mcm as compared to its solubility in other oils, while labrasol and transcutol p had shown higher drug solubility in comparison with other surfactants and cosurfactants respectively which were used in the solubility studies and were used for further studies
The microemulsions were selected from the o/w microemulsion region of pseudoternary phase diagrams which were subjected to thermodynamic stability studies including heating-cooling cycle, centrifugation testing and freeze-thaw cycle
Summary
Treatment involving site-specific delivery to the central nervous system along with prolonged presence and sustain release of a drug to attain steady-state levels is regarded as an ideal effective psychotherapy. Major obstacles to this pathway include the bloodbrain barrier (bbb) prohibiting the entry of the drug into the brain [1, 2]. Intranasal delivery has become prominent as an alternative to invasive delivery systems in order to bypass the bbb and facilitate targeted therapeutic delivery This delivery system utilizes olfactory and trigeminal nerve pathways [3]. Though usage of the nasal route in human medicine has been mostly limited to locally acting agents, in recent years a few systemically acting nasal drug products have been commercialized for menopausal symptoms, pain control, endometriosis and migraine headache [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pharmacy and Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
