Abstract
Pathogenic bacteria remains a primary target of a study due to its prevalence in the environment, specifically the healthcare setting. The use of antibiotics and antimicrobials are essential to treat the symptoms of harmful strains of bacteria. However, although medicinal alternatives exist to kill harmful microorganisms, bacteria have the capability to evolve. Because of this, resistant properties have become a growing problem in the healthcare setting, thus creating various scientific interests of study. High resolution mass spectrometry and imaging analyzes specific ions within a sample thus providing further identification of potential metabolites in Staphylococcus aureus. Therefore, metabolites produced by both resistant and non-resistant strains of bacteria were compared and evaluated. Profiling the metabolic production between the two strains provides a further understanding on how these resistant characteristics were formed, their biological gene function, and how they can potentially be treated.
Highlights
Nosocomial infections, which are prone to hospital settings, are secondary infections that are caused by transferred bacteria
There are alterations that occur in gram-positive bacteria creating enzymes that produce antibiotic resistance such as in Methicillinresistant Staphylococcus aureus (MRSA)
Comparing the wild type to the resistant strains provides information that will aid in locating the origin of production of these resistant properties potentially providing a lead for future treatment options
Summary
Nosocomial infections, which are prone to hospital settings, are secondary infections that are caused by transferred bacteria. These pathogenic microorganisms contain multi-drug resistant properties leading to resistance against commonly used antibiotics. Resistant properties can be formed over time or through alterations of the cellular structure such as the membrane. Staphylococcus aureus is a critical strain of bacteria due to its high presence as a hospital acquired infection, and for its capability to asymptomatically colonize healthy individuals.
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