Abstract
BackgroundThe purpose is to investigate the clinical significance of body morphomics changes in stage III–IV oropharyngeal cancer patients during concurrent chemoradiotherapy (CRT).MethodsFifty patients who underwent CRT were selected for body composition analyses by either availability of pre/post treatment DEXA scans or a novel CT-based approach of body morphomics analysis (BMA). BMA changes (lean psoas and total psoas area) were compared to total lean body mass changes by DEXA scans using two-sample t tests. Pearson correlation was used to compare the BMA measures to head and neck specific quality of life outcomes. Cox hazards model was used to predict mortality and tumor recurrence.ResultsClinically significant declines in total psoas area and lean body mass of similar magnitude were observed in both BMA and DEXA cohorts after CRT. Loss of psoas area (P < 0.05) was associated with greater frailty and mobility issues (3 out of 15 UWQOL domains). Total psoas area is more sensitive for local recurrence than weight changes and T-stage on multivariate analyses.ConclusionsBMA specifically evaluating psoas area appears to correlate with head and neck cancer quality of life physical domains. Pre- and post-treatment total psoas area at L4 appears prognostic for tumor recurrence.
Highlights
The purpose is to investigate the clinical significance of body morphomics changes in stage III–IV oropharyngeal cancer patients during concurrent chemoradiotherapy (CRT)
In this study of locally advanced head and neck cancer patients undergoing concurrent chemoradiation, we aim to characterize the changes in body morphomics before and after CRT by determining the association between these changes with patient-reported quality of life (QoL) and tumor related outcomes
Forty-three of the 93 patients enrolled in prospective phase II chemo-intensity-modulated radiation therapy (IMRT) had pre-treatment and posttreatment follow-up PET/computed tomography (CT) scans available for morphomics analysis and thirty-eight of the forty-three had prospectively completed the University of Washington QOL (UWQOL) and Head and Neck QOL (HNQOL) questionnaires
Summary
The purpose is to investigate the clinical significance of body morphomics changes in stage III–IV oropharyngeal cancer patients during concurrent chemoradiotherapy (CRT). Past studies characterizing changes in TBC have utilized different methods based on fundamentally different techniques, including plain anthropometric measurements (Hyltander et al 1991; Richards et al 2012), neutron activation analysis (MacFie and Burkinshaw 1987), bioelectric impedance measurements (Simons et al 1995), computerized tomography (Smith 2004), and DEXA (Jackson et al 2013; Maturo et al 2003; Koch 1998) These methods may be difficult to obtain at the respective institution, and they have yielded inconsistent results due to intrinsic measurement limitations and variations (Fouladiun et al 2005)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
