Introduction to sessions on 'What can surgeons do for us (and we for them): radiology, pathology, molecular biology and local therapy'

Abstract

A number of important issues surrounding local control of breast cancer continue to attract debate. In breast conserving surgery, the balance between excising sufficient tissue to achieve a satisfactory cosmetic outcome while also achieving adequate long-term local control remains an issue of contention. Despite the review by Singletary [1] indicating that wider excisions are unlikely to reduce local recurrence rates, there remains considerable conflict among surgeons and radiation oncologists as to what is the optimum width of clear margin after breast conserving surgery. There has been increasing focus on trying to identify those patients who are at significant risk for local recurrence from radiological, pathological and molecular biology perspectives. The radiological issues have focused on the role played by magnetic resonance imaging and its value in identifying mammographically occult disease. There remain some radiologists who advocate its widespread use, but evidence of its value is limited [2]. Work by Tabar and coworkers [3] suggests there is a group of patients with widespread casting type microcalcification on mammograms; they consider this to represent neoductgenesis, and it was a poor prognostic sign in their series. Using all of the information that we are provided with by radiologists and incorporating mammographic patterns of cancer into prognosis remains challenging and is an area of controversy. As well as margins, the pathologist assesses a variety of factors that have been shown to influence local recurrence, including histological grade and the presence of lymphatic vascular invasion. Even with accurate pathology, however, it is difficult to identify those who will develop local recurrence with any precision. For this reason, there has been a move to investigate molecular markers. Gene array profiles have been investigated recently but cannot yet accurately identify those patients at risk for local recurrence. Therefore, the greatest influence on local recurrence after breast conserving surgery is currently the surgeon's ability to reduce the volume of disease within the breast, to a level that can be adequately controlled by radiotherapy. Thus, the art of surgery and the ability of the surgeon to remove diseased tissue while retaining sufficient breast tissue to produce a satisfactory outcome is a major reason why such surgery is best carried out by those with a large volume of clinical experience.