Abstract
Plant immunity to disease depends on detection of pathogen-derived molecules by either cell surface or intracellular immune receptors. Plant breeders have long exploited resistance gene-encoded immune receptors but introgression from wild relatives is usually hampered by linkage to deleterious alleles. Identification of immune receptor genes and introduction via the GM method avoids linkage drag and enables construction of more durable stacks of distinct immune receptors with benefits both for resistance strength and genetic durability. Furthermore, useful immune receptor genes from sexually incompatible species can be moved into a crop. I will highlight the benefits of this approach for potato improvement, and comment on a soon-to-be published Royal Society briefing document that calls for proportionate regulation of the GM method for crop improvement.
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