Abstract
Fungus spores are among the most abundant and least well-known of airborne allergens. While ragweed pollen reaches a peak of 5000/m3 of air, fungus spores often exceed 100,000/m3. A majority of pollen types can be identified from air samples and many common and important pollen allergens have been characterized. On the other hand, only a small fraction of different kinds of fungus spores are recognizable and allergen characterization is only beginning. In addition, it has become apparent that fungus allergen preparations from commercial sources vary widely.1,2,3 Among the possible causes for this variability are: 1)intrinsic variation between spores and mycelium with respect to antigen content; 2) somatic mutations causing allergen content changes within single cultures; 3) aging and culture variable changes; 4) strain to strain variability; 5) interspecific variability.
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