Intravoxel incoherent motion imaging in stroke infarct core and penumbra is related to long-term clinical outcome

Abstract

Intravoxel incoherent motion (IVIM) imaging, a contrast agent-free magnetic resonance imaging technique, enables the evaluation of microvascular perfusion abnormalities in acute stroke. Prior research reported reduced IVIM values within the infarct core in acute stroke. However, findings concerning IVIM characteristics in the penumbra have been mixed and the relationship between IVIM and clinical outcomes remains unknown. We employed a longitudinal multimodal imaging approach for ischemic stroke patients (n analyzed=24; pre-/post-treatment and 90-day post-stroke assessments) including IVIM, diffusion-weighted, and contrast-enhanced perfusion-weighted imaging. We evaluated IVIM in relevant stroke areas after endovascular treatment. Reduced post-treatment IVIM perfusion fraction in infarct core and recanalized penumbra was associated with poorer functional recovery at 90-days post-stroke (NIH Stroke Scale [NIHSS]; r=-0.64 and r=-0.69). Including IVIM perfusion fraction increased the explained variance of NIHSS from 42% up to 83% compared to well-known prognostic factors core volume and patient age. Additionally, IVIM perfusion fraction was reduced in the core and recanalized penumbra compared to contralateral healthy tissue, suggesting impaired microvascular reperfusion after endovascular treatment. In conclusion, IVIM characteristics of the infarct core and recanalized penumbra are strong prognostic factors for long-term outcome in stroke patients and IVIM shows promise for characterizing microvascular perfusion in relevant stroke areas.