Abstract

Sensory neurons release calcitonin gene-related peptide (CGRP) upon activation. We have previously reported that activation of sensory neurons increases insulin-like growth factor-I (IGF-I) production, thereby reducing ischemia/reperfusion (I/R)-induced liver injury in mice. Although immunoglobulin has been shown to reduce organ failures by attenuating inflammatory responses in various animal models of sepsis, its therapeutic molecular mechanism(s) is not fully understood. Since sensory neurons have an Fcγ receptor, it is possible that intravenous immunoglobulin reduces reperfusion-induced renal injury by increasing IGF-I production through sensory neuron activation. We examined this possibility in the present study.

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