Intrathecal Fentanyl Versus Intravenous Ondansetron for Shivering Prevention in Cesarean Section: A Comparative Study

Abstract

Background: The incidence of postoperative shivering (PS) following intrathecal anesthesia is a common complication in Cesarean section with potential negative impacts on patient outcomes. The present study aims to evaluate the effectiveness of intrathecal fentanyl versus intravenous ondansetron in preventing post-spinal anesthesia shivering in cesarean section patients. Materials and Methods: A randomized controlled trial was conducted from Feb 2023 to August 2023, involving pregnant women scheduled for cesarean section under intrathecal anesthesia. The study subjects were divided into three groups: group F received intrathecal fentanyl (15 μg) with spinal anesthesia, while group O received intravenous ondansetron (8 mg) added to the usual saline solution. The control group (group C) received only IV fluid before spinal anesthesia and intrathecal bupivacaine without fentanyl. Shivering occurrences were observed and recorded during procedure in the study. Results: The incidence of shivering was significantly lower in the Intrathecal fentanyl and IV ondansetron groups compared to the control group (p=0.0123). Both intrathecal fentanyl and IV ondansetron administration showed effectiveness in reducing shivering during spinal anesthesia. Conclusion: The administration of intrathecal fentanyl and intravenous ondansetron significantly reduced the occurrence of shivering during spinal anesthesia in C-section patients. The present study contributes to advancing knowledge in the field by providing evidence of the preventative effects of these medications on post-spinal anesthesia shivering.