Abstract
The intracerebroventricular injection of neosurugatoxin (2 × 3.2 μg) significantly reduced the specific binding of [ 3H]nicotine but not of [ 3H]cismethyldioxolane in the cerebral cortex, hippocampus and thalamus of rats 3 days after the toxin injection. Scatchard analysis of [ 3H]nicotine binding in the rat cerebral cortex revealed that neosurugatoxin can selectively decrease the maximal binding sites (B max) for [ 3H]nicotine by approximately 38%. A significant decrease in the B max value for [ 3H]nicotine was also observed in this brain region 7 days after the neosurugatoxin injection. Thus, the intracerebroventricular injection of neosurugatoxin can induce a prolonged blockade of brain nicotinic acetylcholine receptors.
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